Data Management

Clinical Trials Simulation: A Publicly Available, Grid-Enabled, GUI-Driven SAS System

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Executive Summary

A clinical trials system developed for Vertex Pharmaceuticals has become publically available on the Biopharmaceutical Network. The system is a SAS/AF based interface in which clinical trials' simulation parameters can be entered; it can operate either on a SAS grid or as a stand-alone process. The statistical details are published in Westfall P.H., Tsai K., Ogenstad S., Tomoiaga A., Moseley S., and Lu Y. (2008). Clinical Trials Simulation: A Statistical Approach. Journal of Biopharmaceutical Statistics 18, 611-630. The system provides a generic template for simulations that are typically required to plan clinical trials.

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