Computational Modeling of Cell Survival Using VHDL

Download Now Date Added: Mar 2010
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The model for cell survival has been implemented using Very High Speed Integrated Circuit Hardware Description Language (VHDL) (Xilinx Tool) taking three input signals: Tumor Necrosis Factor-a (TNF), Epidermal Growth Factor (EGF) and Insulin. Cell survival has been regulated by the interaction of five proteins viz P13K, TNFR1, EGFR, IRS and IKK in a network. In the absence of any one, in protein network leads to cell death. For the EGF input signal the proteins like MEK, ERK, AkT, Rac & JNK have been important for regulation of cell survival.