Effects of MDMA, Methamphetamine and Methylphenidate on Repeated Acquisition and Performance in Rats

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Executive Summary

Repeated-acquisition procedures that include performance controls for effects not specific to acquisition permit the assessment of drug effects on learning on a within-subject, within-session basis. Despite the advantages of this methodology, few studies have examined effects of psychomotor stimulants on repeated acquisition in rodents. The purpose of the present paper was to investigate the effects of MethyleneDioxyMethAmphetamine (MDMA, 0.3 - 10 mg/kg), MethAmphetamine (MA, 0.1 - 3 mg/kg) and MethylPheniDate (MPD,1 - 17 mg/kg) using repeated-acquisition procedures with performance controls in rats using a touch-screen apparatus.

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