Evaluating the Role of Quality Assessment of Primary Studies in Systematic Reviews of Cancer Practice Guidelines
The purpose of this study was to evaluate the role of study quality assessment of primary studies in cancer practice guidelines. Reliable and valid study quality assessment scales were sought and applied to published reports of trials included in systematic reviews of cancer guidelines. Sensitivity analyses were performed to evaluate the relationship between quality scores and pooled odds ratios (OR) for mortality and need for blood transfusion. Results found that that whether trials were classified as high or low quality depended on the scale used to assess them.