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This paper gives an extended overview of challenges creating complex integrated information and computing systems. It covers implementation, legal, and security issues with these processes and how the overall complexity can be reduced using collaboration frameworks with Distributed and High Performance Computing resources in natural sciences disciplines for building integrated public/commercial information system components within the e-Society. Focus is on using a collaboration framework for implementing computing resources, interfaces for data and application interchange, based on current developments regarding infonomics systems, last years case studies within the long-term GEXI project, and Active Source.
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