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Multi-modal image registration is a challenging problem in medical imaging. The goal is to align anatomically identical structures; however, their appearance in images acquired with different imaging devices, such as CT or MR, may be very different. Registration algorithms generally deform one image, the floating image, such that it matches with a second, the reference image, by maximizing some similarity score between the deformed and the reference image. Instead of using a universal, but a priori fixed similarity criterion such as mutual information, the authors propose learning a similarity measure in a discriminative manner such that the reference and correctly deformed floating images receive high similarity scores.
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