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Lean Six Sigma (LSS) is derived from two workflow methodologies, Lean manufacturing and Six Sigma, that began in manufacturing and have expanded to many other nonmanufacturing industries. Lean strategies had a strong initial pull in pharmaceutical manufacturing because benefits could be achieved in brief time periods. The Six Sigma strategy, however, has been gaining more traction due to its focus on reducing variations (defects) in manufacturing, transactional, and documentation processes, thereby reducing the amount of work that must be repeated. Tools from both disciplines are needed to refine processes and outputs to the highest possible levels of speed and quality.
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