Volumetric Quantification of Brain Swelling After Hypobaric Hypoxia Exposure
Conventional qualitative interpretation of two-dimensional cross-sectional MR images gives information about the localization and extension of edematous tissue in patients with brain edema. Changes in adjacent brain slices allow an approximate evaluation of the brain volume. Other approaches in characterization of brain edema are T2 mapping, diffusion weighted imaging, or magnetization transfer contrast imaging, all having the limitation in calculating the real volumes for normal and affected brain tissue. This paper investigates the effect of hypobaric hypoxia exposure on cerebral tissue water in a more comprehensive study of acute mountain sickness.