Beyond Crossing Bres: Probabilistic Tractography of Complex Subvoxel Fibre Geometries

Despite the development of different tractography schemes for reconstruction of fibre pathways, a comprehensive methodology that is capable of providing reliable uncertainty measures of the reconstructed tracts while exploring complex subvoxel fibre geometries, such as fanning, is still missing. This paper proposes a probabilistic approach based on the residual bootstrap statistical technique, applied with detailed subvoxel geometry information obtained using a curve inference technique.