In today's computer world security, integrity, confidentiality of the organization's data is the most important issue. This approach deals with the security of the data that organization manages and works with. It proposes a technique based on generating multiple numbers of keys to secure data using Data Encryption Standard (DES) and RSA algorithm. DES algorithm is used for encryption and decryption. RSA algorithm is used for key generation. The feature of such an approach includes high data security and high feasibility for practical implementation.