Static and dynamic variations, which have negative impact on the reliability of microelectronic systems, increase with smaller CMOS technology. Thus, further downscaling is only profitable if the costs in terms of area, energy and delay for reliability keep within limits. Therefore, the traditional worst case design methodology will become infeasible. Future architectures have to be error resilient, i.e., the hardware architecture has to tolerate autonomously transient errors. In this paper, the authors present an FPGA based rapid prototyping system for multi-processor systems-on-chip composed of autonomous hardware units for error-resilient processing and interconnect.