At the end of last century, e-commerce and ERP become the main methods to improve competitive power, but the integration of enterprise information of ERP and e-commerce system puzzled many enterprises, so in this paper, the integration importance and the main problems that are faced in the integration process are analyzed firstly, and then the enterprise information integration frame of ERP and e-commerce based on web services and multi-agent is proposed to solve platform heterogeneous, language differences, and achieve the two systems information alternation.