How can AI healthcare IT solutions make a difference to the NHS in the next decade? With the UK’s ageing population and an increasing number of patients with complex, long-term conditions, pressure continues to build on an already struggling system. The NHS must find a way to do more with less to ensure its workforce can keep pace with demand. This paper explores the issues surrounding AI in the NHS, determining the main barriers to adoption—ethical, cultural, and logistical—and how they might be overcome. It will look at the clinical settings where AI could be most effective, and how it can be made sustainable, delivering the change the NHS so desperately needs.