In this paper, the authors summarize a special session on multicore/ Multi-Processor System-on-Chip (MPSoC) programming challenges. Wireless multimedia terminals are among the key drivers for MPSoC platform evolution. Heterogeneous multiprocessor architectures achieve high performance and can lead to a significant reduction in energy consumption for this class of applications. However, just designing energy efficient hardware is not enough. Programming models and tools for efficient MPSoC programming are equally important to ensure optimum platform utilization. Unfortunately, this discipline is still in its infancy, which endangers the return on investment for MPSoC architecture designs.