Dendritic Cells Are Defective in Breast Cancer Patients: A Potential Role for Polyamine in This Immunodeficiency

Dendritic cells (DCs) are antigen-presenting cells that are currently employed in cancer clinical trials. However, it is not clear whether their ability to induce tumor-specific immune responses when they are isolated from cancer patients is reduced relative to their ability in vivo. The paper determines the phenotype and functional activity of DCs from cancer patients and investigates the effect of putrescine, a polyamine molecule that is released in large amounts by cancer cells and has been implicated in metastatic invasion, on DCs.

Provided by: BioMed Central Topic: Software Date Added: Feb 2005 Format: PDF

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