Association for Computing Machinery
DNA self-assembly is an emerging technology with potential as a future replacement of conventional lithographic fabrication. A key challenge is the specification of appropriate DNA sequences that are optimal according to specified metrics and satisfy various design rules. To meet this challenge the authors developed a thermodynamics-based design automation tool to evaluate the vast DNA sequence space (2.8k base pairs) and select appropriate sequences. They use this tool to design DNA nanostructures that were previously impossible with existing text distance based tools. They also show that for nanoscale structures their approach produces superior results compared to existing tools.