Journal of Theoretical and Applied Information Technology
A focal point of network studies is the determination of their communities or modules, which help the functional organization and evolution of networks. Modularity can be considered as a function of a dynamic cellular system which performs complex functions in a living cell. How to identify this valuable knowledge resource to build more reliable modules remains one of the most crucial and challenging problems in bioinformatics. The authors propose a state-space model combining temporal topology approach to characterize the spatio-temporal modules of the cell cycle process.