This paper is to examine the effects of knowledge integration and task-technology fit on the implementation of e-business applications. Data were collected by a questionnaire survey sent to 1000 large service enterprises in Taiwan. Of the 1000 questionnaires distributed, 239 were returned, for a response rate of 23.9%. However, 44 respondents indicated that they did not implement any e-business applications in their organizations, and thus 195 completed usable questionnaires were used to perform the statistical analysis. The survey results indicate that knowledge integration and task-technology fit influence the implementation process of e-business applications. Likewise, the implementation process of e-business applications influences the implementation effectiveness of e-business applications.