This report focuses on lycopene and its benefits. Though lycopene was first isolated in 1873, it is only in the last decade that it has become widely recognized as potent antioxidant and a potential protector against the risk of certain types of cancer and cardiovascular diseases. The major food sources of lycopene are tomato-based products. Other good sources are watermelon, guava, papaya, apricots, pink grapefruit, and blood oranges. Natural lycopene has been on the market as a concentrate for a number of years and is present in a variety of supplements.