Wireless Body Sensor Networks (WBSN) systems will enable people to monitor themselves with devices that give proactive warnings of illness so that they can turn to their doctors earlier, when intervention can be the most effective. In this paper, the authors propose a reliable, energy efficient and high throughput routing protocol for heterogeneous Wireless Body Area Networks (WBANs); Multi-Mode Energy-Efficient multi-hop protocol (M2E2). The proposed routing protocol uses fixed deployment of wireless sensors (nodes) in home and mobility support for sensor nodes on human body. The sensor nodes on human body select the best routing by receiving home-signal to minimize energy consumption.