Wireless communication is one of the most effective areas of technology development of time. Wireless communications today covers a very wide array of applications. In this paper, the authors study the performance of general MIMO system, the performance of Zero Forcing (ZF), Linear Least Square Estimator (LLSE), V-BLAST/ZF, V-BLAST/LLSE of 4×4, 4×6 & 4×8 with 4-QAM & 16-QAM modulation in i i d Rayleigh fading channel. They see that SER performance of 4×8 antennas and 4-QAM modulation scheme outperforms others. Result shows that for higher modulation schemes SER performance degrades as well as SER performance increases for higher no of receiver antennas.