Workload variations on Internet platforms such as YouTube, Flickr, LastFM require novel approaches to dynamic resource provisioning in order to meet QoS requirements, while reducing the Total Cost of Ownership (TCO) of the infrastructures. The economy of scale promise of cloud computing is a great opportunity to approach this problem, by developing elastic large scale server infrastructures. However, a proactive approach to dynamic resource provisioning requires prediction models forecasting future load patterns. On the other hand, unexpected volume and data spikes require reactive provisioning for serving unexpected surges in workloads. When workload cannot be predicted, adequate data grouping and placement algorithms may facilitate agile scaling up and down of an infrastructure.