Revisiting Immunosurveillance and Immunostimulation: Implications for Cancer Immunotherapy

Experimental and clinical experience demonstrates that the resolution of a pathogenic challenge depends not only on the presence or absence of an immune reaction, but also on the initiation of the proper type of immune reaction. This review discusses the duality of the role of the immune system in cancer, from the theories of immunosurveillance and immunostimulation to current studies, which illustrate that the immune system has both a protective role and a tumorpromoting role in neoplasia. The potential of using chemotherapy to inhibit a tumor-promoting immune reaction is also discussed.

Provided by: BioMed Central Topic: Software Date Added: Feb 2005 Format: PDF

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