Now-a-days, many applications have been appeared due to the rapid development in the term of telecommunication. One of these applications is the telemedicine where the patients' digital data can transfer between the doctors for farther diagnosis. Therefore, the protection of the exchanged medical data is essential especially when transferring these data in an insecure medium such as the cloud computing environment, where the security is considered a major issue. The first approach apply spatial watermarking technique while the second approach implements a hybrid spatial and transform techniques in order to achieve the needed goal. The experimental results show the efficiency of the proposed approaches and the robustness against various types of attacks.