Healthcare organizations are facing the challenge of delivering personalized services to their patients in a cost-effective and efficient manner. This, in turn, requires advanced IT support for healthcare processes covering both organizational procedures and knowledge-intensive, dynamic treatment processes. Now-a-days, required agility is often hindered by a lack of flexibility in hospital information systems. To overcome this inflexibility a new generation of information systems denoted as Process-Aware Information Systems (PAISs), has emerged. In contrast to data- and function-centered information systems, a PAIS separates process logic from application code and thus provides an additional architectural layer. However, the introduction of process-aware hospital information systems must neither result in rigidity nor restrict staff members in their daily work.