Pipeline leakage wireless monitoring is a difficulty to be solved for a long time in the field of transport pipeline monitoring. In this paper, the authors present a wireless communication system used in pipeline leakage monitoring and based on ARM and ZigBee. The system also contains keyboard, liquid crystal display and temperature sensor. The system provides a wireless measurement and control device with the advantages of multi-channel signal acquisition, highly general application, wireless communication and high anti-interference ability. For the whole system is modular designed, the system can be widely used in complex industrial sites.