First I have maintained several networks in the last six years. Ranging from 250+ PC's with 8 Servers to 1 Server and 25 PC's on a network.
I have used McAfee in a corporate environment for about 5 years at Diversified Plastics, it was very difficult to maintain, upgrades were expensive and time consuming.
I used Norton Enterprise for a little over a year at Life Mortgage, it worked well but quarantined too much, it should have cleaned or deleted more. Yes, I did properly set it up.
As for F-Prot Anti-Vir and AVG, I have had customers with more issues that caused constant (I am talking weekly to monthly) removal and reinstall of these products on a corporate level.
I have only used Computer Associates on peer-to-peer networks.
Since October I have been using NOD32 by ESET and I am currently transferring all my customers as their current subscriptions expire to NOD32. It is inexpensive compared to McAfee, Symantec and Computer Associates.
It was a little more difficult in the initial set up than Symantec but that was my first roll over and once I got the hang of it (the installation pattern needed) it was a breeze.
Now the negative, the updates, they are internet heavy. I solved this by having 1 server get the updates and then the clients grab the updates off the server. The second issue is that I either accidentally keep turning on Advanced Heuristics or it is set to come on by default but you must go in and turn them off for the e-mail otherwise anything with a PDF attachment takes 1 to 2 minutes to download. Turning this off (while keeping "normal? heuristics) is a simple removal of a check box.