email query to a database

in its simplest form, i need a database program with built in email client… or an email program with a built in database

here’s how i would like it to work-
a user sends an email to my database/email client, the database is searched based on the request in the body of the email, a reply with the found data is sent…

is there such a program? is linux or windows better suited for this?

and no, email rules in thunderbird/outlook wont work for me… (i have over 30,000 entries to make in the database) to start, i just need something to search my database automatically from an incoming email