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Exchange 5.5 mail non-delivery

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Some of my users try send mail to certain external addresses that end up in the outbound queue with the following showing up under the Details - Recipients (using a generic sample):
[451 4.1.8 ...Domain of sender address sender@senderdomain does not resolve]
Can anyone explain to me what this means and how to resolve it? Thanks for any help!

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by mgonzales

either the DNS for the target domain does not have an MX recored entered try pinging the mail server that you are trying to send mail to...in the event that this pings then try using telnet and connect to the name of the server and port 25. This isthe port that is used for e-mail servers to send mail between them.....then if that fails try using the ip address and port 25.

Good Luck

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