methods of computers protection

I know an app can protect your tablet and phone: AppLock. However, it is not supported to work on computer.

if I use the encryption program, will my programs be affected, and if yes, how? Also, since there is a password of all passwords for BitLocker, maybe there is such a password for all encryption software? Or it's totally safe to use a good (which one, by the way?) encryption software?

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