Need urgent advice?

I just joined a new job in a well known IT multinational company.

I face the following problems and need advice on actions:

(1) I used to work at my previous employer as a Manager now I am an indiviual contributor as a project maanger in new country

(2) I don’t know where to start and what to do , knowing that My manger is in London and I am in United Arab Emirates and responsible for all Middle east

I am really in amess , my bos not replying, eithe rot my mails nor my phone calls .

Guidance please