One-time only login scripts?

Is there a way under Windows 2000 (server) to put a login script in place that only runs one time?

There are approximately 110 users on this server that log in infrequently. I need the changes to be made, but I don’t want the script to run repeatedly (since it involves a “minor” registry hack). I have tested my script and it works as desired, but I’m a little leary of registry modifications at every subsequent login when they are not needed. Also, there is simply not enough time in my day tomonitor each user’s account and remove the script after the changes have taken effect.

Any ideas would be greatly appreciated…