Hi!. If it's any kind of Unix - reboot in Single User Mode (init S). In this mode you have almost network services stoped. Now try to remove this folders how it was described in #1 (rm -Rf ). Also you may need to unmount this file system and run "fsck" to check if it is filesystem errors. It should help.
In case of NT you should try same things: 1. Check filesystem for errors. 2. Stop IIS services (or whatever do you use). Try to delete files. 3. Check file permissons if it sets to something strange. Take Ownership over those files and try to remove it. 4. In case you still can't remove those files you can try to stop "Protected Storage" service (after stoping IIS service). After this you can remove whatever you want but after deleting reboot your machine ASAP. Last thing is - copy all files which are required to you to another partition/server and format this partition in "Disk Administrator".
Good luck,
Mike Shavrov
MCSE 2000, MCSE+I, Cert. Solaris Admin