First, it's not a magic tool. Someone can't just start the tool up and hack your system, there would need to be some flaws in your present security to allow it.
1st, you would need to allow smb thru your firewall.
2nd, you will have to have avalid account in the domain you are trying to attack.
The reason you are able to view stuff on your local lan is A) there is no firewall between you and your local servers, B) you have a valid account in the domain.
For a test, try loading it up on a system that is not logged into with a domain account.
Or try specifying a remote IP in the address bar. Try it against a web server that is behind a webserver and see what you get.
If you throw a pcket anylyzer on the connection you will see that all it is doing is trying to connect via smb.
Get Hacking Exposed Windows 2000 and you will see how to prevent your systems from these sort of attacks.