Be sure that the DC that the Recipient Update Service points to has the FSMO roles of both Global Catalog server and infrastructure master. To check the RUS properties, in the Exchange System Manager console, go to Recipients/Recipient Update Services and right click on the RUS(es) that you are using, then go to properties and look at the DC that is specified on the General tab. To check the infrastructure master role, open the AD Users and Computers console, right click on the domain name and click "Operations Masters." Click the Infrastructure tab to see which server has that role. Then, to be sure that this server is also a global catalog server, open the AD Sites and Services console and expand it to the [server name]/NTDS settings level. Right click on NTDS settings for the server and click Properties. Make sure the "Global catalog" checkbox is check; is not, check it to make the server a GC server. Then be sure this DC is the one specified in the RUS object.
Hope this helps!