I believe that the Access macro you are talking about does a MAPI call. MAPI is how Outlook works when you have an Exchange server, and Outlook is configured in "corporate/workgroup" mode.
The Access macro makes the right MAPI call, which triggers the e-mail settings from Outlook to be used. Voila! E-mail sent.
Now, Notes is NOT a MAPI client in this situation. It cannot connect to a Domino server using MAPI, as far as I know!
So, my suggestion is that if you have an Access database that needs to e-mail people, then you could do it using an external program call.
Access can call other external programs to do things from within a macro.
You could get a copy of BLAT, a command-line based e-mail program, and have Access call Blat and send the e-mail.
I have used Blat, so that is why I recommend it. IT is here:
http://www.interlog.com/~tcharron/blat.html
(please remove any spaces)
You could write a .BAT file that calls Blat with the appropriate e-mail recipients and message text, then just have the Access macro call the .BAT file.
hope this helps