NTFS Permission

I would think that one easy way would be to make sure they don't have Full Control permissions for any files or folders where you don't want them to do this. Since you don't say what the exact problem is, this is the only sure way I know to stop someone from setting permissions for files and/or folders on an NTFS partition. Alternatively, you could install the NT 4.0 Security Configuration Manager (shipped as a separate option w/SP4, I think), which makes the NTFS file/folder permissions on an NT 4.0 machine look and work just like the Win2k permissions. That way, if they set this attibute on their folders and you wanted to change it, you could easily do this from the server end. Hope this helps!

Don't give them full control.
Also When you create a user and you set up a home directory automatically in usere manager for domains you automatically give them full control permissions. You would have to go into their directories give them properpermissions. Give them change/change (NTFS permissions) or if you're using share permissions give them RWXD and don't give them P or O.

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