Outlook.exe 2003 hogging CPU at 100%

Running XP pro on an HP nx8220 laptop. Only recently has this become a problem, randomly during operations (could be the simplest of operations) the CPU just hangs whilst outlook.exe is running at 100%. The performance is better in safe mode (outlook /safe) but still not as it should be. The same user works fine on other PCs

I’ve tried the following, to no avail.
Removing outlook lookout
Removing activesync

Any ideas welcome. Thanks, Chris.