TrainerSoft Application Bombs

Some of my users are not able to open any .exe's created in TrainerSoft (access based app). They get a general Application Fault error, but no error codes that mean anything significant. I have checked the appcompat.txt file which is the error log for this application issue and it gives no clues as to why it crashes. Most of the users having this issue are running Dell Optiplex 270's with Office 2003 and Access 97. Some of these users are local admins, some are not. But I also have users on GX270's that are able to launch the .exe's with no issues. I ran some software from SysInternals and checked all the DLL's used to run the app... Dll's are exactly the same on a working and non working pc. When I have a fresh install of XP, no apps loaded, the exe's open just fine. Any ideas?