sounds like an explorer.exe error but i agree, we need more...here is some food for thought:
did this used to work? what changed (if anything) add any software? hardware? reinstall anything?
how much free,defragged disk space do you have?
did your up to date anti-virus application scan and find nothing?
do you run Ad-Aware (www.lavasoftusa.com) or spybot or both regularly to clear spyware?
you could try shotgunning the problem by applying all windows critical updates and services packs including drivers. the same for excel and office. is smartworks a current product? what version are your apps please. how much ram. if suspecting ram, check out performance counters, watch the screen at boot
my guess: if nothings changed and this used to work, you have spyware or virus or maybe bad ram...
if this never worked then you need to update your apps to be compatible with latest sp win2k pro