Hey there, and thank you!
Well I spoke with him last night and ended up going by this morning. Yes he is logging in as Administrator, as well as two other user accounts, all obviously have the same issue.
Hijack this appeared clean.
There WAS a virus found 'Dyfica' ut manual removal seems to have worked to some extent as it is no longer found, mind you traces can still ne in there I suppose.
I hate to keep rejecting such good responses but they really are things that have all been done or checked so far.
I usually hav eno problems with the About:blank issues on other machines, this one's just a bitch though.
ONE thing I have noticed, his HOMEPAGE is Yahoo. If I switch his homepage to ANY other page, it will be find UNTIL visiting his home page at Yahoo. Even then all is fine until you click a Yahoo link. ANY link you click on still works, but a minimized about:blank shows up as well, for EVERY LINK in his homepage. Unfortunately he insists on Yahoo as a home page and relies on it for his online email account.
But if you set TR as the home page, everything works fine until visiting Yahoo. Even if his user account is logged out of Yahoo and the generic page is viewed it wil still start the about:blanks. I saw this exact same issue with Excite once, but it mysteriously went away after a few weeks.
I thought maybe explaining how it is being activated may help?
Thanks again!