Does Motherboard Need Replaced?

I've got an HP Touchscreen IQ500 Series IQ524 computer with Vista I'm working on. Was told that lightening may have hit it. When I can get it to turn on I cannot get any of the USB ports to work so it automatically boots into system start-up repair. It gets to a certain point maybe after 15-20 minutes the screen goes like a grey black and has lines running through it vertical and horizontal. As I said i cannot get any USB Keyboard or mouse to work in any of the ports so i cannot even get to the BIOS when I first turn it on. I'm thinking there may be damage to the main motherboard. I've tried resetting the CMOS and changing memory. Any Ideas?