Exchange 5.5 data backup

Im running a NT 4.0 sever with service pack 6. I notice when backing up file with my Seagate software these files get skiped
The item \exchsrvr\DSADATA\edb.log in use – skipped.
The item \exchsrvr\DSADATA\temp.edb in use – skipped.
The item \exchsrvr\imcdata\queue.dat in use – skipped.
The item \exchsrvr\mdbdata\edb.log in use – skipped.
The item \exchsrvr\mdbdata\tmp.edb in use – skipped.

Do these files need to get backed up if they do how do I back up open file with seagate software 7.0