I-search tool bar

Try Spybot Serach & Destroy 1.3 http://www.safer-networking.org/en/index.html

or Adaware SE http://www.lavasoftusa.com/software/adaware/

Either one of these SHOULD work but lately I ahve found that the new Adaware SE works better for some reason.

Go to this link this is the uninstaller.
http://toolbar.isearch.com/uninstall/

If that doesn't work then do the following below be careful though it is a registry hack.

Once you are done run spybot search and destroy or adaware

Start the registry editor. This is done by clicking Start then Run. (The Run dialog will appear.) Type regedit and click OK. (The registry editor will open.)

Delete 'HKEY_LOCAL_MACHINE\SOFTWARE \ Classes \ CLSID \ {1C78AB3F-A857-482e-80C0-3A1E5238A565}', if it exists.

Delete 'HKEY_LOCAL_MACHINE\SOFTWARE \ Microsoft \ Windows \ CurrentVersion \ Explorer\Browser Helper Objects \ {1C78AB3F-A857-482e-80C0-3A1E5238A565}', if it exists.

Delete 'HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Internet Explorer\Toolbar\{1C78AB3F-A857-482e-80C0-3A1E5238A565}', if it exists.

Delete 'HKEY_CURRENT_USER\SOFTWARE\Microsoft\Internet Explorer\Toolbar\WebBrowser\{1C78AB3F-A857-482E-80C0-3A1E5238A565}', if it exists.

Exit the registry editor.

Restart your computer.

Start Windows Explorer and delete:
%SystemDir%\toolbar.dll
Note: %SystemDir% is a variable (?). By default, this is C:\Windows\System (Windows 95/98/Me), C:\WINNT\System32 (Windows NT/2000), or C:\Windows\System32 (Windows XP).

Start Microsoft Internet Explorer.

In Internet Explorer, click Tools -> Internet Options.

Click the Programs tab -> Reset Web Settings.