Do those clients have hard coded IP addresses which should be inside your local network? If so, that condition would generate an IP-Spoofing alert since the ISA server believes that someone is spoofing internal addresses in an external network.
You can overlook IP Spoofing here:
http://www.securityfocus.com/infocus/1674
To disable the IP Spoofing detection in ISA 2004, then check the registry key:
HKEY_LOCAL_MACHINE/SYSTEM/CurrentControlSet/Services/FwEng/Parameters
DWord: SpoofDetection
Value: 0 (Decimal)
Tom Shinder has a pretty good blog on ISA 2004:
http://msmvps.com/shinder/