W2k-drive Letter vs. Folder-Can’t delete

In W2K a secondary disk drive can be accessed via a folder rather than a Drive Letter.
(ie: C:\disk2 vs. D: ) .
Folders on the second drive can not be deleted when accessed via the folder (c:\disk2). Error “Can not delete ‘Folder Name’. Access denied. The source file may be in use.” The folder can be deleted via a command prompt “c:\disk2>rd Folder Name”, or after assigning a drive letter. Any thoughts on why this doesn’t work?