My help-desk telepathy says you're trying to run an older DOS program which requires certain numbers of files and buffers?
Windows ME does not support Real Mode (aka MS-DOS mode) like the Win9x did.
This is what you can try (and this works in Win9x too):
In Explorer, right-click the program you want to run, and then click Properties.
On the Program tab, click Advanced.
Click to select the Prevent MS-DOS-based programs from detecting Windows check box.
Click to clear the Suggest MS-DOS mode as necessary and MS-DOS mode check boxes.
Click OK, and then click OK.
This will cause WinME to try to fool the program into thinking it's running in DOS. Sometimes it works and sometimes it doesn't, it depends on the program, your hardware, and, as far as I can tell, a bit of luck.
Good fortune,
Don