You'd have to check to see if Access/Cold Fusion would be able to read from the cd (without write being enabled).
To test this, I would find the data file on the current hdd, and right-click on it and change it's data arrtibutes to read-only. Then open your database program and see if it will operate on that data file.
If it does, and you know how to change the path of the datafiles to cd, then you can safely place the databases on the cd.
The problem is that this essentially isa backup of the database, and while you can access the data, you cannot update/change the data without making another cd from hdd.
The cd is "readable only" from any programs // the programs will not change/update info on a cd. You'll get an "access denied" or "write-protection" type of error in all probability.