Cannot copy file

I have been working with a compilation of handy files and folders for quite some time but have recently had an error “Error copying file or folder – Cannot copy file”. This occurs when trying to transfer the containing folder from my desktop to either internal/external HD’s. I am able to burn a data DVD but more errors than usual. I have performed registry cleaning (RegCure, ErrorDoctor) without resolve. Is there a simple program to analyze the files in this folder or some consideration I have not mentioned? I noted the issue after integrating my files with zoomsearch and server2go though this may be incidental. Thanks.