Database Security

Hi
How can I secure my database in a way that no one, other than I, can directly access it. Notting that the database is used in a VB Application.
I thought of putting a password, and pass it with the provider in the application, but that means I have to do changes in the application each time I changed the database password. This is why I think it’s not the best solution. so please help me in solving this issue.